USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P18206 USC-OGP 2-DE database:  P18206 P18206 General information about the entry View entry in simple text format Entry name VINC_HUMAN Primary accession number P18206 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Vinculin; AltName: Full=Metavinculin; Short=MV;. Gene name Name=VCL Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0264: pI=5.93; Mw=145692 SPOT OGP-0265: pI=5.89; Mw=144864 SPOT OGP-0266: pI=5.70; Mw=144040 SPOT OGP-0267: pI=5.80; Mw=144040 SPOT OGP-0268: pI=5.91; Mw=143221 SPOT OGP-0269: pI=5.77; Mw=139992 SPOT OGP-0270: pI=5.85; Mw=137618 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0603: pI=5.68; Mw=139931 SPOT OGP-0604: pI=5.74; Mw=137920 SPOT OGP-0605: pI=5.78; Mw=136596 SPOT OGP-0606: pI=5.85; Mw=135284 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0859: pI=5.79; Mw=89803 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1094: pI=6.11; Mw=155482 SPOT OGP-1098: pI=6.19; Mw=142767 SPOT OGP-1099: pI=5.96; Mw=142092 SPOT OGP-1100: pI=6.10; Mw=138108 Cross-references UniProtKB/Swiss-Prot P18206; VINC_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name VINC_HUMAN Primary accession number P18206 Secondary accession number(s) Q16450 Q5SWX2 Q7Z3B8 Q8IXU7 Sequence was last modified on  January 23, 2007 (version 4) Annotations were last modified on  March 15, 2017 (version 195) Name and origin of the protein Description RecName: Full=Vinculin; AltName: Full=Metavinculin; Short=MV; Gene name Name=VCL Encoded on Name=VCL Keywords 3D-structure; Acetylation; Actin-binding; Alternative splicing; Cardiomyopathy; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Polymorphism; Reference proteome; Repeat. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M33308; AAA61283.1; -; mRNA EMBL BX537994; CAD97952.1; -; mRNA EMBL AL596247; CAI13972.1; -; Genomic_DNA EMBL AL731576; CAI13972.1; JOINED; Genomic_DNA EMBL AL731576; CAI39673.1; -; Genomic_DNA EMBL AL596247; CAI39673.1; JOINED; Genomic_DNA EMBL BC039174; AAH39174.1; -; mRNA EMBL L04933; AAA61271.1; -; Genomic_DNA EMBL S87180; AAB21656.1; -; Genomic_DNA EMBL S87175; AAB21656.1; JOINED; Genomic_DNA EMBL S87178; AAB21656.1; JOINED; Genomic_DNA EMBL S87223; AAB21657.1; -; Genomic_DNA EMBL S87218; AAB21657.1; JOINED; Genomic_DNA CCDS CCDS7340.1; -. [P18206-2]; . CCDS CCDS7341.1; -. [P18206-1]; . PIR A35955; A35955; . RefSeq NP_003364.1; NM_003373.3. [P18206-2]; . RefSeq NP_054706.1; NM_014000.2. [P18206-1]; . UniGene Hs.643896; -; . PDB 1RKC; X-ray; 2.70 A; A=1-258 PDB 1RKE; X-ray; 2.35 A; A=1-258 B=882-1134 PDB; 1SYQ; X-ray; 2.42 A A=1-258 PDB; 1TR2; X-ray; 2.90 A A/B=1-1134 PDB; 1YDI; X-ray; 1.80 A A=1-258 PDB; 2GWW; X-ray; 2.72 A A=1-258 PDB; 2HSQ; X-ray; 3.97 A A=1-258 PDB; 2IBF; X-ray; 3.20 A A=1-258 PDB; 3H2U; X-ray; 2.75 A A/C=879-1134 PDB; 3H2V; X-ray; 2.90 A A/B/C/D=879-1134 PDB; 3JBK; EM; 8.20 A M=858-1129 PDB; 3MYI; X-ray; 2.20 A A=959-1130 PDB; 3RF3; X-ray; 1.61 A A/B=1-258 PDB; 3S90; X-ray; 1.97 A A/B=1-252 PDB; 3TJ5; X-ray; 1.99 A A=1-255 PDB; 3TJ6; X-ray; 2.76 A A=1-257 PDB; 3VF0; X-ray; 2.54 A A=856-1134 PDB; 4DJ9; X-ray; 2.25 A A=1-258 PDB; 4EHP; X-ray; 2.66 A A=1-252 PDB; 4LN2; X-ray; 1.00 A B=857-867 PDB; 4LNP; X-ray; 1.41 A B=870-879 PDB; 4PR9; X-ray; 3.20 A A/B/C/D/E/F=891-1134 PDB; 5L0C; X-ray; 3.10 A A/B/C/D=959-1134 PDB; 5L0D; X-ray; 2.75 A A/B/C/D=959-1130 PDB; 5L0F; X-ray; 2.76 A A/B=959-1134 PDB; 5L0G; X-ray; 3.40 A A/B/C/D=959-1134 PDB; 5L0H; X-ray; 2.90 A A=959-1134 PDB; 5L0I; X-ray; 2.45 A A=959-1134 PDB; 5L0J; X-ray; 4.00 A A/B=969-1134 PDBsum; 1RKC; -; . PDBsum 1RKE; -; . PDBsum 1SYQ; -; . PDBsum 1TR2; -; . PDBsum 1YDI; -; . PDBsum 2GWW; -; . PDBsum 2HSQ; -; . PDBsum 2IBF; -; . PDBsum 3H2U; -; . PDBsum 3H2V; -; . PDBsum 3JBK; -; . PDBsum 3MYI; -; . PDBsum 3RF3; -; . PDBsum 3S90; -; . PDBsum 3TJ5; -; . PDBsum 3TJ6; -; . PDBsum 3VF0; -; . PDBsum 4DJ9; -; . PDBsum 4EHP; -; . PDBsum 4LN2; -; . PDBsum 4LNP; -; . PDBsum 4PR9; -; . PDBsum 5L0C; -; . PDBsum 5L0D; -; . PDBsum 5L0F; -; . PDBsum 5L0G; -; . PDBsum 5L0H; -; . PDBsum 5L0I; -; . PDBsum 5L0J; -; . ProteinModelPortal P18206; -; . SMR P18206; -; . BioGrid 113257; 109; . DIP DIP-35570N; -; . IntAct P18206; 44; . MINT MINT-92846; -; . STRING 9606.ENSP00000211998; -; . iPTMnet P18206; -; . PhosphoSitePlus P18206; -; . SwissPalm P18206; -; . BioMuta VCL; -; . DMDM 21903479; -; . DOSAC-COBS-2DPAGE P18206; -; . OGP P18206; -; . REPRODUCTION-2DPAGE IPI00291175; -; . SWISS-2DPAGE P18206; -; . UCD-2DPAGE P18206; -; . EPD P18206; -; . PaxDb P18206; -; . PeptideAtlas P18206; -; . PRIDE P18206; -; . DNASU 7414; -; . Ensembl ENST00000211998; ENSP00000211998; ENSG00000035403. [P18206-1]; . Ensembl ENST00000372755; ENSP00000361841; ENSG00000035403. [P18206-2]; . GeneID 7414; -; . KEGG hsa:7414; -; . UCSC uc001jwe.4; human. [P18206-1]; . CTD 7414; -; . DisGeNET 7414; -; . GeneCards VCL; -; . GeneReviews VCL; -; . H-InvDB HIX0170429; -; . HGNC HGNC:12665; VCL; . HPA CAB002453; -; . HPA HPA002131; -; . HPA HPA063777; -; . MalaCards VCL; -; . MIM 193065; gene; . MIM 611407; phenotype; . MIM 613255; phenotype; . neXtProt NX_P18206; -; . OpenTargets ENSG00000035403; -; . Orphanet 154; Familial isolated dilated cardiomyopathy; . Orphanet 155; Familial isolated hypertrophic cardiomyopathy; . PharmGKB PA37288; -; . eggNOG KOG3681; Eukaryota; . eggNOG ENOG410XSRU; LUCA; . GeneTree ENSGT00550000074411; -; . HOGENOM HOG000007828; -; . HOVERGEN HBG079758; -; . InParanoid P18206; -; . KO K05700; -; . OMA TPGREQN; -; . OrthoDB EOG091G038S; -; . PhylomeDB P18206; -; . TreeFam TF313686; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-445355; Smooth Muscle Contraction; . Reactome R-HSA-5674135; MAP2K and MAPK activation; . Reactome R-HSA-6798695; Neutrophil degranulation; . Reactome R-HSA-6802946; Signaling by moderate kinase activity BRAF mutants; . Reactome R-HSA-6802948; Signaling by high-kinase activity BRAF mutants; . Reactome R-HSA-6802949; Signaling by RAS mutants; . Reactome R-HSA-6802952; Signaling by BRAF and RAF fusions; . Reactome R-HSA-6802955; Paradoxical activation of RAF signaling by kinase inactive BRAF; . SIGNOR P18206; -; . ChiTaRS VCL; human; . EvolutionaryTrace P18206; -; . GeneWiki Vinculin; -; . GenomeRNAi 7414; -; . PRO PR:P18206; -; . Proteomes UP000005640; Chromosome 10; . Bgee ENSG00000035403; -; . CleanEx HS_VCL; -; . ExpressionAtlas P18206; baseline and differential; . Genevisible P18206; HS; . GO GO:0005912; C:adherens junction; ISS:UniProtKB; . GO GO:0005903; C:brush border; ISS:AgBase; . GO GO:0005623; C:cell; ISS:AgBase; . GO GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL; . GO GO:0005911; C:cell-cell junction; ISS:UniProtKB; . GO GO:0030055; C:cell-substrate junction; NAS:UniProtKB; . GO GO:0043034; C:costamere; ISS:UniProtKB; . GO GO:0005856; C:cytoskeleton; TAS:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:1903561; C:extracellular vesicle; IDA:UniProtKB; . GO GO:0005916; C:fascia adherens; IEA:Ensembl; . GO GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0090637; C:inner dense plaque of desmosome; ISS:AgBase; . GO GO:0045121; C:membrane raft; IDA:UniProtKB; . GO GO:0090636; C:outer dense plaque of desmosome; ISS:AgBase; . GO GO:0005886; C:plasma membrane; ISS:AgBase; . GO GO:0002102; C:podosome; IEA:Ensembl; . GO GO:0043234; C:protein complex; IDA:UniProtKB; . GO GO:0034774; C:secretory granule lumen; TAS:Reactome; . GO GO:0035580; C:specific granule lumen; TAS:Reactome; . GO GO:1990357; C:terminal web; ISS:AgBase; . GO GO:0005915; C:zonula adherens; ISS:AgBase; . GO GO:0003779; F:actin binding; IDA:BHF-UCL; . GO GO:0045294; F:alpha-catenin binding; IPI:UniProtKB; . GO GO:0008013; F:beta-catenin binding; ISS:BHF-UCL; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0002162; F:dystroglycan binding; IPI:UniProtKB; . GO GO:0005198; F:structural molecule activity; IEA:InterPro; . GO GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL; . GO GO:0034333; P:adherens junction assembly; IMP:BHF-UCL; . GO GO:0043297; P:apical junction assembly; IMP:UniProtKB; . GO GO:0048675; P:axon extension; IEA:Ensembl; . GO GO:0007155; P:cell adhesion; TAS:UniProtKB; . GO GO:0007160; P:cell-matrix adhesion; TAS:BHF-UCL; . GO GO:0090136; P:epithelial cell-cell adhesion; IMP:BHF-UCL; . GO GO:0030032; P:lamellipodium assembly; ISS:UniProtKB; . GO GO:0002009; P:morphogenesis of an epithelium; IMP:BHF-UCL; . GO GO:0006928; P:movement of cell or subcellular component; TAS:UniProtKB; . GO GO:0006936; P:muscle contraction; TAS:Reactome; . GO GO:0030336; P:negative regulation of cell migration; TAS:UniProtKB; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0070527; P:platelet aggregation; IMP:UniProtKB; . GO GO:0002576; P:platelet degranulation; TAS:Reactome; . GO GO:0034394; P:protein localization to cell surface; IMP:BHF-UCL; . InterPro IPR006077; Vinculin/catenin; . InterPro IPR000633; Vinculin_CS; . PANTHER PTHR18914; PTHR18914; 1; . Pfam PF01044; Vinculin; 3; . SUPFAM SSF47220; SSF47220; 6; . PROSITE PS00663; VINCULIN_1; 1; . PROSITE PS00664; VINCULIN_2; 3; .

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